CHEMICAL TESTING: Developmental Immunotoxicity in Review
نویسندگان
چکیده
منابع مشابه
CHEMICAL TESTING: Developmental Immunotoxicity in Review
Nanotechnology, the engineering of func tional materials at an atomic or molecular scale, has been among the fastest growing fields of science and technology. Worldwide sales of products incorporating nanotechnolo gy are projected to total $2.6 trillion by 2014, according to a 2004 report from Lux Research titled Sizing Nanotechnology’s Value Chain. But with the increasing use of nano materia...
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P renatal and postnatal exposure to persistent organochlorine pollutants, such as polychlorinated biphenyls (PCBs), has been implicated as a possible cause of impaired immune function in children. For example, studies have shown that children who have been exposed to PCBs and related compounds from their mothers' contaminated diets have reduced concentrations of immunoglobulins and increased fr...
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New approaches to immunotoxicity testing are reviewed and discussed. A method of activating T-cells in vivo is presented which circumvents artifacts dur to viability effects encountered with in vitro mitogen assays. The use of adoptive transfer approaches to combine the advantages of in vitro manipulation with in vivo function assays is discussed relative to natural killer cells. The need for a...
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Exposure to arsenic (As) is a global public health problem because of its association with various cancers and numerous other pathological effects, and millions of people worldwide are exposed to As on a regular basis. Increasing lines of evidence indicate that As may adversely affect the immune system, but its specific effects on immune function are poorly understood. Therefore, we conducted a...
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The intricate balance that is the hallmark of the immune system shows vulnerability to any chemical, including pesticides, that can cause structural and functional alterations to the system. The immunotoxic effects of xenobiotics include: histopathologic effects in immune tissues and organs; cellular pathology; altered maturation of immunocompetent cells; changes in B and T cell subpopulations;...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2009
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.117-a149